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- Title
The effect of renal transplantation on left ventricular function, electrocardiography, and mechanical synchrony by gated myocardial perfusion imaging.
- Authors
Crosland, William; Aggarwal, Himanshu; Farag, Ayman; Mehta, Shikha; Mannon, Roslyn B.; Heo, Jaekyeong; Iskandrian, Ami E.; Hage, Fadi G.
- Abstract
<bold>Background: </bold>Depressed left ventricular ejection fraction (LVEF), LV mechanical dyssynchrony (LVMD), and prolonged QTc interval predict poor outcomes in end-stage renal disease (ESRD). Renal transplantation improves mortality in ESRD patients but the effects of transplantation on these indices remain undefined.<bold>Methods: </bold>We identified patients with myocardial perfusion imaging (MPI) before and after renal transplantation. A control group consisted of ESRD patients who underwent 2 MPIs but did not receive a transplant. Changes in LVEF, LVMD indices [phase standard deviation (SD) and bandwidth (BW)] by MPI, and electrocardiogram (ECG) indices were determined.<bold>Results: </bold>The study population consisted of 32 ESRD patients (53% male, 50 ± 11 years, 59% African American, 65% diabetic). The second MPI was performed 31 months (13-59 months) after renal transplantation. LVEF (72 ± 10% vs. 67 ± 10%, P < 0.001) but not SD (22 ± 15° vs. 22 ± 11°, P = 0.9) or BW (58 ± 35° vs. 57 ± 29°, P = 0.9) improved after transplantation. There were no changes in these indices in the control group. QTc (425 ± 30 ms vs. 447 ± 32 ms, P = <0.001) but not QRS (90 ± 21 ms vs. 90 ± 21 ms, P = 0.9) improved significantly after renal transplantation.<bold>Conclusions: </bold>LVEF and QTc improved after renal transplantation but LVMD indices and QRS did not change, which suggests that LVMD and electrical dyssynchrony may be irreversible in ESRD.
- Subjects
MYOCARDIAL perfusion imaging; TRANSPLANTATION of organs, tissues, etc.; CHRONIC kidney failure; VENTRICULAR ejection fraction; SYNCHRONIC order
- Publication
Journal of Nuclear Cardiology, 2019, Vol 26, Issue 6, p1962
- ISSN
1071-3581
- Publication type
journal article
- DOI
10.1007/s12350-018-1411-8