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- Title
[18F]-NaF PET/CT imaging in cardiac amyloidosis.
- Authors
Van Der Gucht, Axel; Galat, Arnault; Rosso, Jean; Guellich, Aziz; Garot, Jérôme; Bodez, Diane; Plante-Bordeneuve, Violaine; Hittinger, Luc; Dubois-Randé, Jean-Luc; Evangelista, Eva; Sasanelli, Myriam; Chalaye, Julia; Meignan, Michel; Itti, Emmanuel; Damy, Thibaud; Garot, Jérôme; Dubois-Randé, Jean-Luc
- Abstract
Cardiac amyloidosis (CA) is recognized as a common cause of restrictive cardiomyopathy and heart failure due to the deposition of insoluble proteins in the myocardial interstitium. We emphasize the role of [18F]-sodium fluoride (NaF) PET/CT as a potential noninvasive tool to identify and differentiate the transthyretin-related cardiac amyloidosis from the light-chain cardiac amyloidosis. We report cases of a 73-year-old man and a 75-year-old woman followed in our center for congestive heart failure with marked alteration of the left ventricular ejection fraction due to familial transthyretin Val122Ile cardiac amyloidosis and light-chain cardiac amyloidosis, respectively, confirmed on endomyocardial biopsy.
- Subjects
POSITRON emission tomography; ELECTROCARDIOGRAPHY; CARDIAC amyloidosis; HEART biopsy; DIAGNOSIS
- Publication
Journal of Nuclear Cardiology, 2016, Vol 23, Issue 4, p846
- ISSN
1071-3581
- Publication type
journal article
- DOI
10.1007/s12350-015-0287-0