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- Title
Intra-patient reproducibility of myocardial SPECT imaging with Tl.
- Authors
Backus, Barbra E.; Verburg, Frederik A.; Romijn, R. Leo; Konijnenberg, Mark W.; Beekman, Freek J.; Verzijlbergen, J. Fred
- Abstract
Background: To define the physical and clinical reproducibility of Tl myocardial perfusion SPECT (MPS), this study assesses the variation between two repeated rest Tl MPS with repositioning only, with a two-hour time interval and with phantom measurements as a reference. Methods: Three anthropomorphic thorax phantoms were filled with Tl. For each phantom five repeated Tl MPS were obtained. In addition, in 20 patients repeated Tl rest-MPS and in 26 patients early and delayed Tl rest-MPS were performed. Quantitative analysis was done using MunichHeart. Statistical methods were used to calculate variability. Visual analysis was performed by 2 independent observers. Results: The average variation between repeated phantom MPS was 0.5% (95% confidence interval (CI): −0.4% to 1.4%). For patient scans this was −5.0% (95% CI: −2.5% to −7.5%) and between early and delayed Tl MPS −15.5% (95% CI: −11.7% to −19.3%). Visual assessment revealed no clinical significant differences between rest Tl and repeated or delayed Tl MPS. Conclusions: Repositioning in phantom Tl MPS does not cause significant variation. Repeated Tl MPS in patients shows 5.0% decrease of Tl in 30 minutes, which increases to 15% during a two-hour time interval without quantitative or visual regional differences. This decrease indicates a time-related washout of Tl, but does not change clinical diagnosis.
- Subjects
SINGLE-photon emission computed tomography; POSITRON emission tomography; CORONARY disease; MYOCARDIAL infarction; MEDICAL radiography
- Publication
Journal of Nuclear Cardiology, 2009, Vol 16, Issue 1, p97
- ISSN
1071-3581
- Publication type
Article
- DOI
10.1007/s12350-008-9011-7