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- Title
Ovulation-stimulation drugs and cancer risks: a long-term follow-up of a British cohort.
- Authors
dos Santos Silva, I.; Wark, P. A.; McCormack, V. A.; Mayer, D.; Overton, C.; Little, V.; Nieto, J.; Hardiman, P.; Davies, M.; MacLean, A. B.; Silva, I dos Santos
- Abstract
To assess long-term health effects of ovarian-stimulation drugs we followed-up for over 20 years a British cohort of 7355 women with ovulatory disorders, 43% of whom were prescribed ovarian-stimulation drugs, and identified a total of 274 deaths and 367 incident cancers. Relative to the general population, the cohort experienced lower mortality from most causes, including from all neoplasms combined, and lower incidence of cervical cancer, but higher incidence of cancers of the breast (relative risk: 1.13; 95% CI 0.97, 1.30) and corpus uteri (2.02; 1.37, 2.87). There were, however, no significant differences in the risk of cancers of the breast, corpus uteri, ovary, or of any other site, between women who had been prescribed ovarian-stimulation drugs and those who had not. Further analyses by type of drug and dose revealed a dose-response gradient in the risk of cancer of the corpus uteri (P for linear trend=0.03), with women given >or=2250 mg of clomiphene having a 2.6-fold (2.62; 0.94, 6.82) increase in risk relative to those who were not treated. These findings do not support strong associations between ovulation-stimulation drugs and cancer risks, but they indicate the need for continued monitoring to establish whether risks are elevated in certain subgroups of users.
- Subjects
UNITED Kingdom; ENGLAND; OVULATION; MENSTRUAL cycle; ANOVULATION; CANCER risk factors; COMPARATIVE studies; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; TIME; TUMORS; EVALUATION research; FERTILITY drugs; PHARMACODYNAMICS
- Publication
British Journal of Cancer, 2009, Vol 100, Issue 11, p1824
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/sj.bjc.6605086