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- Title
Desmoplasia Influenced Recurrence of Disease and Mortality in Stage III Colorectal Cancer within Five Years after Surgery and Adjuvant Therapy.
- Authors
Zippi, Maddalena; De Toma, Giorgio; Minervini, Giovanni; Cassieri, Claudio; Pica, Roberta; Colarusso, Diodoro; Stock, Simon; Crispino, Pietro
- Abstract
Background/Aims: In patients with colon cancer who undergo resection for potential cure, 40-60% have advanced locoregional disease (stage III). Those who are suitable for adjuvant treatment had a definite disease-free-survival benefit. The aim of the present study was to demonstrate whether the presence of desmoplasia influenced the mortality rate of stage III colorectal cancer (CRC) within 5 years from the surgery and adjuvant therapy. Patients and Methods: Sixty-five patients with stage III CRC underwent resection and adjuvant therapy. Qualitative categorization of desmoplasia was obtained using Ueno's stromal CRC classification. Desmoplasia was related to mortality using Spearman correlation and stratified with other histological variables (inflammation, grading) that concurred to the major determinant of malignancy (venous invasion and lymph nodes) using the Chi-square test. Result: The 5-year survival rate was 65% and the relapse rate was 37%. The mortality rate in patients with immature desmoplasia was 86%, 27% in intermediate desmoplasia, and 0% in mature desmoplasia (Spearman correlation coefficient: -0.572, P = 0.05). Conclusion: Immature desmoplasia appears tobe associated with disease recurrence and mortality in stage III CRC patients.
- Subjects
CANCER patients; CANCER relapse; CHI-squared test; COLON tumors; COMBINED modality therapy; CONNECTIVE tissues; INFLAMMATION; RECTUM tumors; STATISTICS; TUMOR classification; DATA analysis; FIBROSIS; TREATMENT effectiveness; DATA analysis software
- Publication
Saudi Journal of Gastroenterology, 2017, Vol 23, Issue 1, p39
- ISSN
1319-3767
- Publication type
Article
- DOI
10.4103/1319-3767.199114