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- Title
DHPS-Mutated Isolates of Pneumocystis jirovecii from HIV-Infected Individuals: Analysis of Related ITS Genotypes.
- Authors
VALERIO, ANTONELLA; TRONCONI, ELISA; MAZZA, FRANCESCA; CARGNEL, ANTONIETTA; FANTONI, GIOVANNA; ATZORI, CHIARA
- Abstract
The article presents a study that investigates the possible association between specific internal transcribed spacers (ITS) and dihydropteroate synthase (DHPS) types. In this study, the DHPS and the ITS loci of Pneumocystis jirovecii isolates from HIV-infected patients were typed. Results suggested an association between DHPS mutations and severity of Pneumocystis pneumonia, as judged by the outcome, the number of deaths, and the need for aggressive respiratory resistance.
- Subjects
DRUG resistance; HIV-positive persons; SULFONAMIDE drugs; PNEUMOCYSTIS pneumonia; LUNG diseases
- Publication
Journal of Eukaryotic Microbiology, 2006, Vol 53, pS108
- ISSN
1066-5234
- Publication type
Article
- DOI
10.1111/j.1550-7408.2006.00192.x