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- Title
Treatment of the acquired immune deficiency syndrome-related Kaposi's sarcoma with bleomycin as a single agent.
- Authors
Lassoued, Kaïss; Clauvel, Jean-Pierre; Katlama, Christine; Janier, Michel; Picard, Catherine; Matheron, Sophie; Lassoued, K; Clauvel, J P; Katlama, C; Janier, M; Picard, C; Matheron, S
- Abstract
A nonrandomized trial was conducted to assess the efficiency and toxicity of bleomycin as a single agent in treatment of non-life-threatening AIDS-related Kaposi's sarcoma (KS). Sixty patients were enrolled in this study. They all had a disseminated and progressive non-life-threatening AIDS-related KS associated with systemic symptoms and/or CD4 lymphocyte count less than 400/mm3. Thirty patients were treated with intramuscular bleomycin (5 mg/d for 3 days every 2 or 3 weeks) and 30 others with a slow continuous intravenous infusion of bleomycin (6 mg/m3/d for 4 days every 4 weeks). The mean duration of therapy was 5 months (range, 2 to 24 months). A partial response was observed in 29 patients (48.3%) and the disease was stabilized in 18 additional patients (30%). Bleomycin failed in 21.6% of patients. Therapy had to be discontinued in two patients because of side effects. Thus bleomycin as a single agent is a good alternative therapy for AIDS-related KS.
- Publication
Cancer (0008543X), 1990, Vol 66, Issue 9, p1869
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19901101)66:9<1869::AID-CNCR2820660903>3.0.CO;2-S