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- Title
CD8+ cytotoxic T lymphocyte responses to lytic proteins of human herpes virus 8 in human immunodeficiency virus type 1-infected and -uninfected individuals.
- Authors
Wang, Q J; Jenkins, F J; Jacobson, L P; Meng, Y X; Pellett, P E; Kingsley, L A; Kousoulas, K G; Baghian, A; Rinaldo, C R Jr
- Abstract
T cell immunity to lytic proteins of herpesviruses is important in host control of infection. We have characterized the cytotoxic T lymphocyte (CTL) response to 5 human herpesvirus 8 (HHV-8) homologues of lytic proteins in HHV-8-seropositive individuals. HLA class I-restricted, CD8(+) CTL responses to >/=1 HHV-8 lytic protein were detected in all 14 HHV-8-seropositive study subjects tested, with or without human immunodeficiency virus type 1 (HIV-1) infection, but not in any of 5 HHV-8-seronegative individuals. Seven of these study subjects with both HHV-8 and HIV-1 infection had greater anti-CTL reactivity to glycoprotein H (open-reading frame 22) than did the 7 study subjects infected only with HHV-8. Moreover, there was a strong, inverse correlation between HIV-1 load and glycoprotein H-specific CTL lysis in the study subjects infected with both viruses. CTL reactivity to HHV-8 lytic proteins may be involved in host control of HHV-8-related diseases, such as Kaposi's sarcoma.
- Subjects
COMPARATIVE studies; GENES; HERPESVIRUSES; HISTOCOMPATIBILITY antigens; HIV; IMMUNITY; IMMUNOPHENOTYPING; KAPOSI'S sarcoma; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PROTEINS; RESEARCH; T cells; VIRAL antigens; VIRUSES; AIDS-related opportunistic infections; VIRAL load; EVALUATION research; HIV seronegativity
- Publication
Journal of Infectious Diseases, 2000, Vol 182, Issue 3, p928
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1086/315777