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- Title
Targeting Lipopolysaccharides by the Nontoxic Polymyxin B Nonapeptide Sensitizes Resistant...
- Authors
Rose, Frank; Heuer, Kay U.; Sibelius, Ulf; Hombach-Klonisch, Sabine; Kiss, Ladislau; Seeger, Werner; Grimminger, Friedrich
- Abstract
Examines the impact of polymyxin B nonapeptide (PMBN) on human neutrophil-effected killing of the serum- and phagocytosis-resistant Escherichia coli strains C14 and O111 by coapplying serum with PMBN or with neutrophils. Preparation of human granulocytes and complement-depleted serum; Granulocyte-bacteria cocultures; Measurement of neutrophil bactericidal capacity and phagocytosis.
- Subjects
ESCHERICHIA coli; NEUTROPHILS; PEPTIDES; POLYMYXIN; SERUM
- Publication
Journal of Infectious Diseases, 2000, Vol 182, Issue 1, p191
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/315669