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- Title
Mucosal healing predicts the long-term prognosis of intestinal Behçet's disease.
- Authors
Yim, Sun Mie; Kim, Duk Hwan; Lee, Hyun Jung; Jang, Hui Won; Park, Soo Jung; Hong, Sung Pil; Kim, Tae Il; Kim, Won Ho; Cheon, Jae Hee
- Abstract
<bold>Background: </bold>Mucosal healing (MH) has emerged as a therapeutic goal in the treatment of inflammatory bowel disease; however, little is known about the impact of MH on the prognosis of intestinal Behçet's disease (BD).<bold>Aim: </bold>We investigated whether MH could predict the prognosis of intestinal BD.<bold>Methods: </bold>We retrospectively reviewed the medical records of 80 patients with intestinal BD who underwent colonoscopy within 3 months after clinical remission. The clinical recurrence rate according to the presence or absence of MH was evaluated using the Kaplan-Meier method and the log-rank test. In order to evaluate MH as an independent prognostic factor, a multivariate analysis using Cox proportional hazards regression model was performed including other potential factors for the relapse of intestinal BD.<bold>Results: </bold>The number of patients with active ulcers at the time of clinical remission was 57 (71.3%), while 23 patients (28.7%) were experiencing MH. In the active ulcer group, 39 patients (68.4%) experienced recurrence during the follow-up period, whereas 7 patients (30.4%) recurred in the MH group. The cumulative recurrence rate was significantly higher in the active ulcer group than in the MH group (P < 0.001). A multivariate analysis identified active ulcers at the time of clinical remission as an independent predictive factor for relapse.<bold>Conclusion: </bold>Our study demonstrates that MH is an independent factor predictive of long-term prognosis of intestinal BD. MH might be the ultimate therapeutic goal in the treatment of intestinal BD.
- Publication
Digestive Diseases & Sciences, 2014, Vol 59, Issue 10, p2529
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-014-3198-z