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- Title
Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex.
- Authors
Motohiro Shiotani; Kyoko Nakano; Emiko Yamauchi; Yoshiya Oda; Satoru Hosokawa; Toyohiko Aoki
- Abstract
Proteomic analysis was carried out for neuronal vacuolation in rat retrosplenial cortex (RSC) induced by MK-801, a N-methyl-D-aspartate (NMDA) receptor antagonist. Female rats were given a single subcutaneous (sc) injection of either MK-801 (9 mg/kg in saline) or saline. Comparison of changes in proteins in the RSC region between MK-801- and saline-treated groups revealed that MK-801 induced changes in six proteins involved in vesicular transport (vesicle-fusing ATPase) and glycolysis (fructose-bisphosphate aldolase C, triosephosphate isomerase, and glyceraldehyde-3-phosphate dehydrogenase).
- Publication
Journal of Toxicological Sciences, 2011, Vol 36, Issue 1, p131
- ISSN
0388-1350
- Publication type
Article
- DOI
10.2131/jts.36.131