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- Title
Acute Kidney Injury in Rhabdomyolysis: A 5-Year Children's Hospital Network Study.
- Authors
Pinto, Jamie M.; Ison, Gregory; Kasselman, Lora J.; Naganathan, Srividya
- Abstract
Rhabdomyolysis is a skeletal muscle injury that can cause myoglobinuria and acute kidney injury (AKI). Risk factors for AKI in children are not clearly understood with no standardized treatment guidelines for rhabdomyolysis. Our study explores factors associated with AKI and management of pediatric patients with rhabdomyolysis. Medical records from a children's hospital network over a 5-year period were retrospectively reviewed. The results are described with respect to the presence or absence of AKI. Of the 112 patients who met the inclusion criteria, AKI incidence was 7.1% (n = 8), with all affected patients having exertional etiology. The overall mean age was 13.5 years; patients without AKI were younger than patients with AKI (13.3 versus 17; p < 0.001). Using regression models for hypothesis generation, we found that patients with AKI were more likely to be older (OR = 1.44, 95%CI [1.11–2.19]; p = 0.03), have myoglobinuria (OR = 22.98, 95%CI [2.05–432.48]; p = 0.02), and have received intravenous bicarbonate (OR = 16.02, 95%CI [1.44–228.69]; p = 0.03). In our study, AKI was uncommon and associated with older age, myoglobinuria and bicarbonate treatment. Larger, prospective studies are needed to further understand AKI risk factors and optimal management of pediatric rhabdomyolysis.
- Subjects
NEW Jersey; RISK assessment; WOUNDS &; injuries; CREATININE; DRUG side effects; PHYSIOLOGIC salines; MULTIPLE regression analysis; SEX distribution; RHABDOMYOLYSIS; ACUTE kidney failure; RETROSPECTIVE studies; DESCRIPTIVE statistics; AGE distribution; HOSPITALS; BLOOD plasma substitutes; BICARBONATE ions; ODDS ratio; RACE; CREATINE kinase; HEAT; INTRAVENOUS therapy; ELECTRONIC health records; MEDICAL records; ACQUISITION of data; PAIN; CONFIDENCE intervals; LENGTH of stay in hospitals; DISEASE risk factors; DISEASE complications; CHILDREN
- Publication
Healthcare (2227-9032), 2024, Vol 12, Issue 17, p1717
- ISSN
2227-9032
- Publication type
Article
- DOI
10.3390/healthcare12171717