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- Title
Use of noninvasive measurement of the indocyanine green plasma disappearance rate in patients with septic shock.
- Authors
Gutiérrez-Morales, Isabel; Loza-Vázquez, Ana; Sánchez-Román†, José Antonio; Grilo-Reina, Antonio; Navarro-Puerto, María Asunción
- Abstract
Introduction. Our aim was to analyse the relation between serial values of the indocyanine green plasma disappearance rate (ICG-PDR) with hospital mortality in the first 48 hours of ICU admission in patients with septic shock. Methods. A prospective observational study was carried out over 12 months of patients admitted to the ICU with septic shock. Each patient underwent noninvasive determination of ICG-PDR at 24 and 48 hours with the LiMON® module. Follow- up was performed until hospital discharge or exitus. Results. 63 patients. Age 61.1±12.3 years. 60.3% men. SOFA score on admission 8.7±3.3, APACHE II score was 27.9±10.7 points. A total of 44.4% of patients died. The ICGPDR values in the first 24 hours of ICU admission were lower in nonsurvivors: 10.5 (5.7-13.0)%/min vs. 15.9 (11.4-28.0)%/ min, p <0.001. Furthermore, in nonsurvivors, there was no improvement in ICG-PDR between 24 h and 48 h, while in survivors, there was an increase of 25%: 15.9 (11.4-28.0)%/min and 20.9 (18.0-27.0)%/min, p=0.020. The silhouette measure of ICG-PDR cohesion and separation for the clusters analysed (nonsurvivors and survivors) was satisfactory (0.6). ICGPDR< 11.7%/min was related to in-hospital mortality, ICGPDR> 18%/min to survival, and the interval between 11.7% and 18%/min covered a range of uncertainty. In the two-stage cluster, ICG-PDR, SOFA and APACHE II present satisfactory predictive scores 24 hours after patient admission. Conclusions. ICG-PDR in our setting is a useful clinical prognostic tool and could optimise the decision tree in patients with septic shock.
- Subjects
INDOCYANINE green; SEPTIC shock; CRITICAL care medicine; SEPSIS; SHOCK (Pathology)
- Publication
Revista Española de Quimioterapia, 2024, Vol 37, Issue 5, p401
- ISSN
0214-3429
- Publication type
Article
- DOI
10.37201/req/029.2024