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- Title
Anti-Inflammatory Effect of Dietary Pentadecanoic Fatty Acid Supplementation on Inflammatory Bowel Disease in SAMP1/YitFc Mice.
- Authors
Singh, Drishtant; Mehghini, Paola; Rodriguez-Palacios, Alexander; Di Martino, Luca; Cominelli, Fabio; Basson, Abigail Raffner
- Abstract
Background/Objectives: Dietary fats have been linked to the increasing incidence of chronic diseases, including inflammatory bowel diseases (IBD), namely, Crohn's disease (CD). Methods: This study investigated the impact of pentadecanoic acid (C15:0), a type of an odd-numbered chain saturated fatty acid, for its potential anti-inflammatory properties in different mouse models of experimental IBD using the SAMP1/YitFc (SAMP) mouse line (14- or 24-week-old), including chronic ileitis and DSS-induced colitis. To quantitively assess the effect of C:15, we tested two dosages of C:15 in selected experiments in comparison to control mice. Intestinal inflammation and intestinal permeability were used as primary outcomes. Results: In ileitis, C:15 supplementation showed an anti-inflammatory effect in SAMP mice (e.g., a reduction in ileitis severity vs. control p < 0.0043), which was reproducible when mice were tested in the DSS model of colitis (e.g., reduced permeability vs. control p < 0.0006). Of relevance, even the short-term C:15 therapy prevented colitis in mice by maintaining body weight, decreasing inflammation, preserving gut integrity, and alleviating colitis signs. Conclusions: Collectively, the findings from both ileitis and colitis in SAMP mice indicate that C:15 may have therapeutic effects in the treatment of IBD (colitis in the short term). This promising effect has major translational potential for the alleviation of IBD in humans.
- Subjects
COLITIS prevention; INFLAMMATION prevention; SHORT-chain fatty acids; RESEARCH funding; INTESTINAL barrier function; BODY weight; TREATMENT effectiveness; SEVERITY of illness index; INFLAMMATORY bowel diseases; MICE; EXPERIMENTAL design; ANIMAL experimentation; ILEITIS; SATURATED fatty acids; DIETARY supplements; EVALUATION
- Publication
Nutrients, 2024, Vol 16, Issue 17, p3031
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16173031