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- Title
EBV‐Positive Classic Hodgkin Lymphoma and Primary Nodal T‐Cell/NK‐Cell Lymphoma Arising in the Background of Follicular Lymphoma.
- Authors
Raychaudhuri, Suravi; Dong, Zhao Ming; Knowles, Scott; Graf, Solomon; Piccaluga, Pier Paolo
- Abstract
EBV‐positive primary nodal T‐cell/NK cell lymphoma (TNKL) is a rare diagnosis with a poor prognosis. No relationship with follicular lymphoma (FL), classic Hodgkin lymphoma (cHL), or other non‐Hodgkin lymphomas is established. We describe a case of Epstein–Barr virus (EBV)‐positive cHL and EBV‐positive primary nodal TNKL in the background of an antecedent FL, with all 3 subtypes identified in a single lymph node biopsy from an immunocompetent patient. Intensive frontline therapy achieved only a temporary response, with subsequent rapid progression associated with hemophagocytic lymphohistiocytosis (HLH). We discuss the relationship of the three lymphoma subtypes and the potential roles of EBV and immune dysregulation as contributing factors to this previously undescribed composite lymphoma.
- Subjects
HODGKIN'S disease; FOLLICULAR lymphoma; HEMOPHAGOCYTIC lymphohistiocytosis; LYMPHOMAS; LYMPH nodes
- Publication
Case Reports in Hematology, 2024, Vol 2024, p1
- ISSN
2090-6560
- Publication type
Case Study
- DOI
10.1155/2024/8810646