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- Title
Worse Wilms’ Tumor Outcomes Associated With Chemical Complementarity for Multiple T-Cell Receptor CDR3-CMV Epitope Pairs.
- Authors
RIGBY, KASEY L.; DIAZ, MICHAEL J.; GOZLAN, ETIENNE C.; KACSOH, DOROTTYA B.; SONG, JOANNA J.; HUDOCK, TABITHA R.; CHOBRUTSKIY, ANDREA; CHOBRUTSKIY, BORIS I.; BLANCK, GEORGE
- Abstract
Background/Aim: Wilms’ tumors are pediatric renal tumors that generally have a good prognosis and outcomes. Viral illnesses have been linked to development of neoplasms and should be considered as a factor that could modulate overall survival. Materials and Methods: We considered recently developed adaptive immune receptor, genomics and bioinformatics approaches to assess the potential impact of cytomegalovirus (CMV) infections in Wilms’ tumor. Results: T-cell receptor (TCR) complementarity determining region-3 (CDR3) amino acid sequences from Wilms’ tumor specimens represented by the Therapeutically Applicable Research to Generate Effective Treatments dataset were compared with known anti-CMV TCR CDR3s, indicating that cases representing the anti-CMV TCR CDR3s had worse outcomes. Then, a chemical complementarity scoring approach for the Wilms’ tumor, TCR CDR3s and a series of CMV antigens further indicated that cases representing a higher chemical complementarity to the CMV antigens had worse outcomes. Conclusion: Overall, we present a potentially novel method to assess CMV infections and identify patients who could benefit from therapies that address such infections.
- Subjects
AMINO acid sequence; CYTOMEGALOVIRUS diseases; KIDNEY tumors; OVERALL survival; T cells
- Publication
Cancer Genomics & Proteomics (1109-6535), 2024, Vol 21, Issue 5, p439
- ISSN
1109-6535
- Publication type
Article
- DOI
10.21873/cgp.20462