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- Title
Efficacy of Glucagon-like Peptide-1 Receptor Agonists in Overweight/Obese and/or T2DM Adolescents: A Meta-analysis Based on Randomized Controlled Trials.
- Authors
Min Dai; Senjie Dai; Lihu Gu; Zhiyi Xiang; Anyi Xu; Siyu Lu; Yang Yang; Cong Zhou
- Abstract
Objective: The aim of this meta-analysis was to investigate the effect of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on blood glucose and weight in adolescents with overweight/obesity and/or type 2 diabetes mellitus (T2DM) aged <18 years. Methods: PubMed, Embase, Web of Science, and Cochrane Library were searched for all randomized controlled trials (RCTs) up to August 2023 comparing GLP-1RAs with placebo in overweight/obese and/or T2DM adolescents and extracted relevant data for meta-analysis. Results: Fourteen RCTs were included in the meta-analysis with a total of 1,262 participants. Results revealed that the GLP-1RAs group had a more significant reduction in glycosylated hemoglobin A1c (HbA1c; risk difference (RD)=-0.34%, p<0.001) than the control group. However, there was no difference in fasting plasma glucose [fasting plasma glucose (FPG); RD=-2.07 mg/dL, p=0.065] between the two groups. Nonetheless, the experimental group that received exenatide showed no significant reduction in HbA1c (p=0.253) and FPG (p=0.611) between the two groups. The GLP-1RAs group had a more significant decline in body weight (RD=-4.28 kg, p=0.002) and body mass index (BMI) (RD=-1.63 kg/m2, p=0.002) compared to the control group. The experimental group was given liraglutide (RD=-2.31 kg, p=0.038) or exenatide (RD=-2.70 kg, p<0.001). Compared to the control group, the experimental group had a more significant drop in body weight than the control group. However, for the experimental group that received liraglutide, the BMI had a no significant reduction between the two groups (RD=-0.81 kg/m2, p=0.260). For the experimental group using exenatide, BMI declined more significantly in the intervention group than in the control group (RD=-1.14 kg/m2, p<0.001). Conclusion: This study showed that GLP-1RAs reduced HbA1c, FPG, and weight loss in overweight/obese and/or T2DM adolescents. Liraglutide was better than exenatide in terms of glucose reduction. Nevertheless, in terms of weight control, exenatide was more effective than liraglutide.
- Subjects
GLUCAGON-like peptide-1 agonists; WEIGHT loss; PREPROCEDURAL fasting; MEDICAL information storage &; retrieval systems; GLYCOSYLATED hemoglobin; GLYCEMIC control; META-analysis; EXENATIDE; DESCRIPTIVE statistics; BLOOD sugar; MEDLINE; TYPE 2 diabetes; DRUG efficacy; MEDICAL databases; CHILDHOOD obesity; ONLINE information services; EVALUATION; ADOLESCENCE
- Publication
Journal of Clinical Research in Pediatric Endocrinology, 2024, Vol 16, Issue 3, p323
- ISSN
1308-5727
- Publication type
Article
- DOI
10.4274/jcrpe.galenos.2024.2024-1-5