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- Title
Long-term effects of an egg-protein hydrolysate on cognitive performance and brain vascular function: a double-blind randomized controlled trial in adults with elevated subjective cognitive failures.
- Authors
Adams, Micah S.; Mensink, Ronald P.; Plat, Jogchum; Joris, Peter J.
- Abstract
Purpose: Short-term intake of the egg-protein hydrolysate Newtricious (NWT)-03 improved executive function, but underlying mechanisms and long-term effects, including other cognitive domains, are unknown. Methods: A 36-week randomized controlled trial involving 44 overweight/obese individuals experiencing elevated Subjective Cognitive Failures (SCF; aged 60–75 years) assessed the impact of daily consumption of 5.7 g of NWT-03 or placebo powders on cognitive performance (psychomotor speed, executive function, memory) and Cerebral Blood Flow (CBF), a marker of brain vascular function. Cognitive performance was evaluated using a neurophysiological test battery (CANTAB) and CBF was measured using magnetic resonance imaging perfusion method Arterial Spin Labeling (ASL). Serum samples were collected to determine brain-derived neurotrophic factor (BDNF) concentrations. Results: Anthropometrics, and energy and nutrient intakes remained stable throughout the trial. NWT-03 was well tolerated, and compliance was excellent (median: 99%; range: 87–103%). No overall intervention effects were observed on cognitive performance or CBF, but post-hoc analyses revealed significant improvements on executive function in women, but not men. Specifically, a reduction of 74 ms in reaction latency on the multitasking task (95% CI: −134 to −15; p = 0.02), a reduction of 9 between errors (95%CI: −14 to −3; p < 0.001), and a reduction of 9 total errors (95%CI: −15 to −3; p < 0.001) on the spatial working memory task were found in women. No intervention effects were observed on serum BDNF concentrations (p = 0.31). Conclusion: Long-term consumption of NWT-03 improved multitasking abilities and working memory in women with elevated SCF. Brain vascular function remained unaffected. Sex differences in executive function require additional clarification.
- Subjects
BRAIN physiology; THERAPEUTIC use of proteins; EGGS; COGNITIVE testing; FOOD consumption; DATA analysis; RESEARCH funding; BRAIN; EXECUTIVE function; POWDERS; NEUROPHYSIOLOGY; TREATMENT effectiveness; RANDOMIZED controlled trials; MAGNETIC resonance imaging; NUTRITIONAL requirements; PSYCHOLOGY of movement; SERUM; COGNITION disorders; MEMORY; BRAIN-derived neurotrophic factor; STATISTICS; CEREBRAL circulation; ANTHROPOMETRY; CONFIDENCE intervals; SPACE perception; OBESITY; BIOMARKERS; DIETHYLSTILBESTROL; OLD age
- Publication
European Journal of Nutrition, 2024, Vol 63, Issue 6, p2095
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-024-03394-y