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- Title
Anti-mycotic trial therapy for neonatal septicemia caused a drop in the mortality rate.
- Authors
Salman, Salman Khalid; Taha Al-Quhli, Sawsan Qahtan; Abdulateef, Yasir Mufeed
- Abstract
Objective. Neonatal respiratory infections continue to be a significant cause of illness and death in newborn infants. the aim was to determine the association of pneumonia in 60 neonates with septicemia and it is role in the morbidity and mortality of neonates in two Neonatal Intensive Care Units (NICU) in Al-Ramadi Teaching Hospital for Maternity and Children. Material and methods. All infants in this study were diagnosed with septicemia and were on empirical antimicrobial therapy. An early morning nasogastric tube (NG tube) was used to collect swallowed sputum by suction for culture and sensitivity. Outcomes. All neonates were diagnosed with septicemia. The positive bacterial blood culture was 28 (46.7%). The NG-tube culture revealed 100% fungal growth, 49 (81.6%) Candida albicans, Candida tropicalis 6 (10%) and Cryptococcus laurentii 5 (8.3 %). The NG-tube culture revealed 100% bacterial growth Staphylococcus aureus 8 (13.3%), Streptococcus pneumonia 5 (8.3), Klebsiella pneumonia 25 (41.6%), Klebsiella oxytoca 2 (3.3), Acinetobacter baumannii 12 (20%), Pseudomonas aeruginosa 3 (5%) and Pseudomonas putida 2 (3.3%). 42 (70%) of patients were received antifungal drug (fluconazole), 34 (80.9%) of them showed improvement, while 8 (19%) showed no improvement. 18 (30%) of patients received no medication, of which 3 (16.6%) showed improvement, while 15 (83.3%) showed no improvement. Conclusion. Bacterial pneumonia with mycotic co-infection in neonates with septicemia may lead to an increase in the mortality rate. During this study, using antimycotic medications led to a drop in the mortality rate to zero.
- Subjects
MYCOSES; NEONATAL intensive care units; NEONATAL infections; NEONATAL death; ACINETOBACTER baumannii
- Publication
Romanian Journal of Infectious Diseases / Revista Romana de de Boli Infectioase, 2024, Vol 27, Issue 2, p118
- ISSN
1454-3389
- Publication type
Article
- DOI
10.37897/RJID.2024.2.14