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- Title
Tailoring of apoptotic bodies for diagnostic and therapeutic applications:advances, challenges, and prospects.
- Authors
Miao, Xiaoyu; Wu, Xiaojin; You, Wenran; He, Kaini; Chen, Changzhong; Pathak, Janak Lal; Zhang, Qing
- Abstract
Apoptotic bodies (ABs) are extracellular vesicles released during apoptosis and possess diverse biological activities. Initially, ABs were regarded as garbage bags with the main function of apoptotic cell clearance. Recent research has found that ABs carry and deliver various biological agents and are taken by surrounding and distant cells, affecting cell functions and behavior. ABs-mediated intercellular communications are involved in various physiological processes including anti-inflammation and tissue regeneration as well as the pathogenesis of a variety of diseases including cancer, cardiovascular diseases, neurodegeneration, and inflammatory diseases. ABs in biological fluids can be used as a window of altered cellular and tissue states which can be applied in the diagnosis and prognosis of various diseases. The structural and constituent versatility of ABs provides flexibility for tailoring ABs according to disease diagnostic and therapeutic needs. An in-depth understanding of ABs' constituents and biological functions is mandatory for the effective tailoring of ABs including modification of bio membrane and cargo constituents. ABs' tailoring approaches including physical, chemical, biological, and genetic have been proposed for bench-to-bed translation in disease diagnosis, prognosis, and therapy. This review summarizes the updates on ABs tailoring approaches, discusses the existing challenges, and speculates the prospects for effective diagnostic and therapeutic applications. Highlights: Apoptotic bodies (ABs), a type of cellular waste product discovered as a biomaterial with therapeutic potential ABs mediated intercellular communication, including the transmission of biological signals and biological substances Apoptotic bodies exhibit significant research and application potential in the prevention, diagnosis, and treatment of diseases. The functionality of apoptotic bodies can be enhanced through drug loading, surface modification, and biomimetic preparation.
- Subjects
APOPTOTIC bodies; BIOENGINEERING; CELL communication; CELL physiology; EXTRACELLULAR vesicles
- Publication
Journal of Translational Medicine, 2024, Vol 22, Issue 1, p1
- ISSN
1479-5876
- Publication type
Article
- DOI
10.1186/s12967-024-05451-w