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- Title
Benefits and Challenges of Drug-Coated Balloons in Peripheral Artery Disease: From Molecular Mechanisms to Clinical Practice.
- Authors
Tataru, Dan-Alexandru; Lazar, Florin-Leontin; Onea, Horea-Laurentiu; Homorodean, Calin; Ober, Mihai-Claudiu; Olinic, Maria; Spinu, Mihail; Olinic, Dan-Mircea
- Abstract
Multiple clinical trials have reported favorable outcomes after drug-coated balloon therapy for peripheral artery disease in above-the-knee and below-the-knee lesions and in both de novo and in-stent restenosis. However, there are still insufficient data to identify and tackle the risk factors associated with a higher risk of restenosis, which is the primary concern for patients who are treated with an endovascular approach. A modern armamentarium, which includes improved lesion preparation techniques such as plaque modification balloons, mechanical atherectomy, intravascular lithotripsy, and imaging, is crucial for obtaining better long-term clinical outcomes. Moreover, a better understanding of the molecular properties of drug-coated balloons has led to improved devices that could tackle the shortcomings of previous generations. This comprehensive review focuses on drug-coated balloon technology as a tool to treat peripheral artery disease and the effects of the molecular mechanisms involved in preventing vascular restenosis.
- Subjects
PERIPHERAL vascular diseases; ATHERECTOMY; BRUTON tyrosine kinase; RAPAMYCIN; PACLITAXEL
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 16, p8749
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25168749