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- Title
Association between early-life mosquito repellents exposure and ADHD-like behaviours.
- Authors
Zhou, Cheng; Fu, Weiwen; Wei, Xinyu; Zhang, Zixing; Wang, Bin; Fang, Xinyu
- Abstract
Background Limited research has explored the impact of mosquito repellents exposure during early life on ADHD symptoms. This study aimed to explore the associations of exposure to mosquito repellents from pregnancy to 3 years old and the prevalence of ADHD-like behaviours among children aged 3–9 years, and further identify the sensitive exposure period. Methods A cross-sectional study was conducted, including 12 275 children in Hefei City, China. Exposure was self-reported via primary caregivers. ADHD-like behaviours were measured by the Swanson, Nolan and Pelham, version IV scale (SNAP-IV), and Conners' Parent Rating Scale (CPRS). Cross-over analysis, binary logistic regression and linear regression were employed. Results After adjusting for confounding variables, early-life exposure to mosquito repellents was associated with a higher risk of ADHD-like behaviours (OR = 1.81, 95% CI = 1.49–2.19). By comparing the strength of the association for each subgroup, we found exposure during 1–3 years old was a sensitive period (OR = 1.89, 95% CI = 1.25–2.87) by the cross-over analysis. Furthermore, we found a dose–response relationship in which the likelihood of ADHD-like behaviours increased with children's early-life mosquito repellents exposure dose. Conclusions Early-life exposure to mosquito repellents is linked with an elevated risk of ADHD-like behaviours in children, with a sensitive period identified during 1–3 years old.
- Subjects
CHINA; RISK factors of attention-deficit hyperactivity disorder; RISK assessment; CROSS-sectional method; PATERNAL age effect; ATTENTION-deficit hyperactivity disorder; RESEARCH funding; MATERNAL age; QUESTIONNAIRES; LOGISTIC regression analysis; SEX distribution; NOMADS; PREMATURE infants; SMOKING; INSECT baits &; repellents; DESCRIPTIVE statistics; CHI-squared test; AGE distribution; CROSSOVER trials; ODDS ratio; LOW birth weight; DOSE-response relationship in biochemistry; MARITAL status; ENVIRONMENTAL exposure; INDOOR air pollution; DATA analysis software; CONFIDENCE intervals; PREGNANCY complications; ALCOHOL drinking; SENSITIVITY &; specificity (Statistics); REGRESSION analysis; PASSIVE smoking; EDUCATIONAL attainment; EMPLOYMENT; FETUS; CHILDREN; PREGNANCY
- Publication
Journal of Public Health, 2024, Vol 46, Issue 3, p366
- ISSN
1741-3842
- Publication type
Article
- DOI
10.1093/pubmed/fdae076