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- Title
Detection of Fetal NRBCs in Maternal Blood of Pregnant Carriers of β-Thalassemia Using Anti-γ and Anti-ε Monoclonal Antibodies.
- Authors
MAVROU, ARIADNI; KOLIALEXI, AGGELIKI; ANTSAKLIS, ARISTIDES; KRIKOS, XENOFON; KORATZIS, ASTERIS; METAXOTOU, CATHERINE
- Abstract
A bstract: Fetal nucleated red blood cells (NRBCs) entering maternal circulation during pregnancy constitute a potential source of material for safe and reliable noninvasive prenatal diagnosis. The increased prevalence of β-thalassemia mutations in countries like Greece may create a problem, making it difficult to distinguish between NRBCs of fetal or maternal origin. Use of Ab against embryonic hemoglobin ε may increase specificity for fetal NRBC detection. In the present study, Ab against embryonic hemoglobin ε was used in the first and second trimesters of pregnancy in order to determine if specificity for fetal NRBC detection could be increased.
- Publication
Annals of the New York Academy of Sciences, 2001, Vol 945, Issue 1, p151
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2001.tb03877.x