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- Title
Cellular Support Systems for Alginate Microcapsules Containing Islets, as Composite Bioartificial Pancreas.
- Authors
CALAFIORE, RICCARDO; LUCA, GIOVANNI; CALVITTI, MARIO; NERI, LUCA M.; BASTA, GIUSEPPE; CAPITANI, SILVANO; BECCHETTI, ENNIO; BRUNETTI, PAOLO
- Abstract
A bstract: To improve the functional performance of microencapsulated islets, we examined the effects of putative cellular support systems, consisting of rat purified Sertoli cells (SC) and astrocytes (AA), on coenveloped allogeneic islets. Coincubation of islets with SC but not AA, resulted in significant stimulation of β cell mitogenesis, coupled with a significant increase in in vitro glucose-stimulated insulin release. Preliminarily, the xenotransplantation of coencapsulated rat islets and homologous SC significantly prolonged remission of hyperglycemia in diabetic mice.
- Publication
Annals of the New York Academy of Sciences, 2001, Vol 944, Issue 1, p240
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2001.tb03836.x