We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A Paradigm for Cancer Treatment Using the Retinoblastoma Gene in a Mouse Model.
- Authors
NIKITIN, ALEXANDER YU.; RILEY, DANIEL J.; LEE, WEN-HWA
- Abstract
A bstract: Discovery of tumor suppressor genes has provided a rational approach to cancer prevention and treatment. Loss of retinoblastoma susceptibility gene ( Rb) function is a rate-limiting event in the development of human and mouse cancers. Establishment of animal models of cancer associated with Rb deficiency allowed us to develop and test long-awaited approaches to genetic correction for treating tumors in vivo. Recent studies demonstrated that (1) prevention of carcinogenesis is achieved by correction of gene copy number in Rb+/− mice, and (2) reconstitution of Rb gene functions is sufficient for suppression of neoplasia in immunocompetent mice. These results fulfill a promise of cancer treatment by reconstitution of tumor suppressor function.
- Publication
Annals of the New York Academy of Sciences, 1999, Vol 886, Issue 1, p12
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.1999.tb09396.x