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- Title
Hyaluronidase and degranulation inhibitors from the edible roots of Oenanthe javanica including seric acids F and G that were obtained by heating.
- Authors
Murata, Toshihiro; Katagiri, Tatsuo; Osaka, Masaaki; Yamauchi, Shohei; Yoshimura, Kenshi; Kawada, Manami; Fujii, Yu; Suzuki, Yuka; Sasaki, Kenroh
- Abstract
Oenanthe javanica is a vegetable grown in East Asia and Australia in which the roots and aerial parts are boiled together to make certain traditional dishes. Nineteen compounds (1-19) were isolated from O. javanica roots and the chemical structures of 2 new norlignans were determined. The inhibitory effects of the compounds on hyaluronidase and degranulation in RBL-2H3 cells were evaluated to determine antiallergic and antiinflammation activities. Saponins (2-4) and the new norlignan seric acid G (12) were among the active compounds identified. Seric acid G (12), a methoxy derivative of seric acid F (11), was obtained as an interconverting mixture of 3:1 trans - cis isomers. Seric acids F and G (11, 12) were derived from seric acids C (10) and E, respectively, by decarboxylation and dehydration reactions that occurred during heating. It was confirmed by HPLC analysis that all eleven of the O. javanica cultivars contained seric acid C (10).
- Subjects
EAST Asia; AUSTRALIA; HYALURONIDASES; ACIDS; SAPONINS; VEGETABLE farming; CHEMICAL structure; LIGNANS; ISOMERS; DEHYDRATION reactions
- Publication
Bioscience, Biotechnology & Biochemistry, 2021, Vol 85, Issue 2, p369
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1093/bbb/zbaa042