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- Title
Oral malignant melanoma – the effect of coarse fractionation radiotherapy alone or with adjuvant carboplatin therapy.
- Authors
Murphy, S.; Hayes, A. M.; Blackwood, L.; Maglennon, G.; Pattinson, H.; Sparkes, A. H.
- Abstract
A retrospective study was undertaken of dogs presented to the Animal Health Trust for treatment of oral malignant melanoma, without radiographic evidence of pulmonary metastases. Group 1 ( n = 13) received radiotherapy of the primary and any lymph node metastases (4 weekly fractions of 9 Gy); and group 2 ( n = 15) were treated the same but additionally received between two and six doses carboplatin at 300 mg m−2 every 3 weeks. Median survival times for the two groups were 307 and 286 days, respectively ( P > 0.05). In addition, carboplatin therapy did not significantly reduce the proportion of dogs dying due to metastases (three from group 1 and four from group 2). We found no evidence of a beneficial effect of carboplatin therapy over radiotherapy alone.
- Subjects
MELANOMA; RADIOTHERAPY; METASTASIS; DOG diseases; TUMORS in animals; VETERINARY medicine; ANIMAL health
- Publication
Veterinary & Comparative Oncology, 2005, Vol 3, Issue 4, p222
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/j.1476-5810.2005.00082.x