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- Title
Fiber-optic nanosensors for single-cell monitoring.
- Authors
Vo-Dinh, Tuan; Kasili, Paul
- Abstract
This article is an overview of the fabrication, operating principles, and applications of fiber-optic nanobiosensors with the capability of in-vivo analysis at the single-cell level. Recently, the cross-disciplinary integration of nanotechnology, biology, and photonics has been revolutionizing important areas in molecular biology, especially diagnostics and therapy at the molecular and cellular level. Fiber-optic nanobiosensors are a unique class of biosensor that enable analytical measurements in individual living cells and the probing of individual chemical species in specific locations within a cell. This article provides a review of the research performed in our laboratory and discusses the usefulness and potential of this nanotechnology-based biosensor system in biological research and its applications to biomonitoring of individual cells.
- Subjects
BIOSENSORS; SINGLE cell lipids; APOPTOSIS; NANOTECHNOLOGY; MOLECULAR biology; PHOTONICS; ANALYTICAL chemistry
- Publication
Analytical & Bioanalytical Chemistry, 2005, Vol 382, Issue 4, p918
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-005-3256-7