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- Title
Rapid determination of telmisartan in pharmaceuticals and serum by the parallel catalytic hydrogen wave method.
- Authors
Xu, Maotian T.; Song, Junfeng F.; Li, Ning
- Abstract
The polarographic characteristics of telmisartan have been investigated in 0.8 mol L-1 NH3.H2O–NH4Cl (pH 8.9)–0.01 mol L-1 H2O2 as supporting electrolyte. The results demonstrate that the polarographic reduction wave at ca. -1.30 V in the absence of H2O2 is a catalytic hydrogen wave, and the reduction wave enhanced by H2O2 is a so-called parallel catalytic hydrogen wave. The analytical sensitivity of the parallel catalytic hydrogen wave is ca. 60 times higher than that of the corresponding catalytic hydrogen wave. Based on the parallel catalytic hydrogen wave a novel method has been developed for determination of telmisartan by linear sweep polarography. The calibration curve is linear in the range 2.0×10-8–2.0×10-6 mol L-1 and the detection limit is 1.0×10-8 mol L-1. The precision is excellent with relative standard deviations of 2.6% at a concentration of 1.0×10-7 mol L-1 telmisartan. The proposed method has been applied to the direct determination of the telmisartan in capsule forms and biological samples. The proposed method has been proved to be advantageous over existing CZE and MEKC methods in simplicity, rapidity, and reproducibility.
- Subjects
DRUG analysis; CAPILLARY electrophoresis; ANGIOTENSIN converting enzyme; CALCIUM antagonists; POLAROGRAPHY; SERUM; HYPERTENSION
- Publication
Analytical & Bioanalytical Chemistry, 2003, Vol 377, Issue 7/8, p1184
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-003-2197-2