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- Title
Iron‐Catalyzed Reductive Ethylation of Imines with Ethanol.
- Authors
Vayer, Marie; Morcillo, Sara P.; Dupont, Jennifer; Gandon, Vincent; Bour, Christophe
- Abstract
Abstract: The borrowing hydrogen strategy has been applied to the ethylation of imines with an air‐stable iron complex as precatalyst. This approach opens new perspectives in this area as it enables the synthesis of unsymmetric tertiary amines from readily available substrates and ethanol as a C2 building block. A variety of imines bearing electron‐rich aryl or alkyl groups at the nitrogen atom could be efficiently reductively alkylated without the need for molecular hydrogen. The mechanism of this reaction, which shows complete selectivity for ethanol over other alcohols, has been studied experimentally and by means of DFT computations.
- Subjects
ETHYLATION; IMINES; TERTIARY amines; ALKYL group; ETHANOL; ARYL group
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 12, p3282
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201800328