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- Title
Improved Biocompatibility of Black Phosphorus Nanosheets by Chemical Modification.
- Authors
Qu, Guangbo; Liu, Wei; Zhao, Yuetao; Gao, Jie; Xia, Tian; Shi, Jianbo; Hu, Ligang; Zhou, Wenhua; Gao, Jiejun; Wang, Huaiyu; Luo, Qian; Zhou, Qunfang; Liu, Sijin; Yu, Xue ‐ Feng; Jiang, Guibin
- Abstract
Black phosphorus nanosheets (BPs) show great potential for various applications including biomedicine, thus their potential side effects and corresponding improvement strategy deserve investigation. Here, in vitro and in vivo biological effects of BPs with and without titanium sulfonate ligand (TiL4) modification are investigated. Compared to bare BPs, BPs with TiL4 modification (TiL4@BPs) can efficiently escape from macrophages uptake, and reduce cytotoxicity and proinflammation. The corresponding mechanisms are also discussed. These findings may not only guide the applications of BPs, but also propose an efficient strategy to further improve the biocompatibility of BPs.
- Subjects
PHOSPHORUS; BIOCOMPATIBILITY; TITANIUM compounds; LIGANDS (Chemistry); MACROPHAGES
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 46, p14680
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201706228