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- Title
Glycation Reactivity of a Quorum-Sensing Signaling Molecule.
- Authors
Tsuchikama, Kyoji; Gooyit, Major; Harris, Tyler L.; Zhu, Jie; Globisch, Daniel; Kaufmann, Gunnar F.; Janda, Kim D.
- Abstract
Reported herein is that (4 S)-4,5-dihydroxy-2,3-pentanedione (DPD) can undergo a previously undocumented non-enzymatic glycation reaction. Incubation of DPD with viral DNA or the antibiotic gramicidin S resulted in significant biochemical alterations. A protein-labeling method was consequently developed that facilitated the identification of unrecognized glycation targets of DPD in a prokaryotic system. These results open new avenues toward tracking and understanding the fate and function of the elusive quorum-sensing signaling molecule.
- Subjects
GLYCOSYLATION; REACTIVITY (Chemistry); CHEMICAL reactions; QUORUM sensing; MICROBIAL genetics; PENTANEDIONE; ESTERIFICATION
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 12, p4070
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201511911