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- Title
Optimization of S-adenosyl-L-methionine production by Kluyveromyces lactis on whey in batch culture using a mathematical model.
- Authors
Mincheva, Kremena; Kamburova, Veselka; Balutzov, Venelin
- Abstract
Growth, lactose utilization and S-adenosyl-l-methionine (AdoMet) production by Kluyveromyces lactis AM-65 on whey in batch fermentation were investigated and an unstructured model of the process has been derived. The optimal set of parameters was estimated by fitting the model to experimental results. After incubation for 20 h the optimal fermentation conditions (28.5 °C, pH 5.3, agitation at 270 rpm) resulted in AdoMet production at 1.55 g l-1.
- Subjects
FERMENTATION; INDUSTRIAL microbiology; LACTOSE; METHIONINE; HYDROGEN-ion concentration; KLUYVEROMYCES
- Publication
Biotechnology Letters, 2002, Vol 24, Issue 21, p1773
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1023/A:1020605120240