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- Title
Optimization of glycerol feeding for clavulanic acid production by Streptomyces clavuligerus with glycerol feeding.
- Authors
Chen, Kuo-Cheng; Lin, Yun-Huin; Tsai, Cheng-Min; Hsieh, Chen-Hao; Houng, Jer-Yiing
- Abstract
Glycerol at 10–20 g l-1 increased clavulanic acid production by Streptomyces clavuligerus in shake-flask culture. The biosynthesis of clavulanic acid continued for longer by feeding glycerol and production increased to 250 mg l-1 compared with 115 mg l-1 without feeding. In fermenter batch culture, degradation of clavulanic acid began after 72 h. With glycerol feeding in fed-batch culture, clavulanic acid production was not only increased further to about 280 mg l-1 but also remained stable up to 130 h.
- Subjects
GLYCERYL ethers; LIPIDS; CLAVULANIC acid; GLYCERIN; ETHERS; CARBOXYLIC acids
- Publication
Biotechnology Letters, 2002, Vol 24, Issue 6, p455
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1023/A:1014553109425