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- Title
Association of paraspinal muscle water-fat MRI-based measurements with isometric strength measurements.
- Authors
Schlaeger, Sarah; Inhuber, Stephanie; Rohrmeier, Alexander; Dieckmeyer, Michael; Freitag, Friedemann; Klupp, Elisabeth; Weidlich, Dominik; Feuerriegel, Georg; Kreuzpointner, Florian; Schwirtz, Ansgar; Rummeny, Ernst J.; Zimmer, Claus; Kirschke, Jan S.; Karampinos, Dimitrios C.; Baum, Thomas
- Abstract
<bold>Objectives: </bold>Chemical shift encoding-based water-fat MRI derived proton density fat fraction (PDFF) of the paraspinal muscles has been emerging as a surrogate marker in subjects with sarcopenia, lower back pain, injuries and neuromuscular disorders. The present study investigates the performance of paraspinal muscle PDFF and cross-sectional area (CSA) in predicting isometric muscle strength.<bold>Methods: </bold>Twenty-six healthy subjects (57.7% women; age: 30 ± 6 years) underwent 3T axial MRI of the lumbar spine using a six-echo 3D spoiled gradient echo sequence for chemical shift encoding-based water-fat separation. Erector spinae and psoas muscles were segmented bilaterally from L2 level to L5 level to determine CSA and PDFF. Muscle flexion and extension maximum isometric torque values [Nm] at the back were measured with an isokinetic dynamometer.<bold>Results: </bold>Significant correlations between CSA and muscle strength measurements were observed for erector spinae muscle CSA (r = 0.40; p = 0.044) and psoas muscle CSA (r = 0.61; p = 0.001) with relative flexion strength. Erector spinae muscle PDFF correlated significantly with relative muscle strength (extension: r = -0.51; p = 0.008; flexion: r = -0.54; p = 0.005). Erector spinae muscle PDFF, but not CSA, remained a statistically significant (p < 0.05) predictor of relative extensor strength in multivariate regression models (R2adj = 0.34; p = 0.002).<bold>Conclusions: </bold>PDFF measurements improved the prediction of paraspinal muscle strength beyond CSA. Therefore, chemical shift encoding-based water-fat MRI may be used to detect subtle changes in the paraspinal muscle composition.<bold>Key Points: </bold>• We investigated the association of paraspinal muscle fat fraction based on chemical shift encoding-based water-fat MRI with isometric strength measurements in healthy subjects. • Erector spinae muscle PDFF correlated significantly with relative muscle strength. • PDFF measurements improved prediction of paraspinal muscle strength beyond CSA.
- Subjects
MUSCLE strength; SKELETAL muscle; MAGNETIC resonance imaging; VASTUS lateralis
- Publication
European Radiology, 2019, Vol 29, Issue 2, p599
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-018-5631-8