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- Title
Pre-TACE kurtosis of ADC<sub>total</sub> derived from histogram analysis for diffusion-weighted imaging is the best independent predictor of prognosis in hepatocellular carcinoma.
- Authors
Wu, Li-Fang; Rao, Sheng-Xiang; Xu, Peng-Ju; Yang, Li; Chen, Cai-Zhong; Liu, Hao; Huang, Jian-Feng; Fu, Cai-Xia; Halim, Alice; Zeng, Meng-Su
- Abstract
<bold>Purpose: </bold>To determine the feasibility of pre-TACE IVIM imaging based on histogram analysis for predicting prognosis in the treatment of unresectable hepatocellular carcinoma (HCC).<bold>Materials and Methods: </bold>Fifty-five patients prospectively underwent 1.5T MRI 1 week before TACE. Histogram metrics for IVIM parameters and ADCs maps between responders and non-responders with mRECIST assessment were compared. Kaplan-Meier, log-rank tests and Cox proportional hazard regression model were used to correlate variables with time to progression (TTP).<bold>Results: </bold>Mean (p = 0.022), median (p = 0.043), and 25th percentile (p < 0.001) of perfusion fraction (PF), mean (p < 0.001), median (p < 0.001), 25th percentile (p < 0.001) and 75th percentile (p = 0.001) of ADC(0,500), mean (p = 0.005), median (p = 0.008) and 25th percentile (p = 0.039) of ADCtotal were higher, while skewness and kurtosis of PF (p = 0.001, p = 0.005, respectively), kurtosis of ADC(0,500) and ADCtotal (p = 0.005, p = 0.001, respectively) were lower in responders compared to non-responders. Multivariable analysis demonstrated that mRECIST was associated with TTP independently, and kurtosis of ADCtotal had the best predictive performance for disease progression.<bold>Conclusion: </bold>Pre-TACE kurtosis of ADCtotal is the best independent predictor for TTP.<bold>Key Points: </bold>• mRECIST was associated with TTP independently. • Lower kurtosis and higher mean for ADCs tend to have good response. • Pre-TACE kurtosis of ADC total is the best independent predictor for TTP.
- Subjects
LIVER cancer; PROGNOSIS; KURTOSIS; PROPORTIONAL hazards models; DISEASE progression; TUMOR treatment; HEPATOCELLULAR carcinoma; LIVER tumors; LONGITUDINAL method; MAGNETIC resonance imaging; PILOT projects; PREDICTIVE tests; CHEMOEMBOLIZATION; DIAGNOSIS; THERAPEUTICS
- Publication
European Radiology, 2019, Vol 29, Issue 1, p213
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-018-5482-3