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- Title
Structural brain alterations of Down's syndrome in early childhood evaluation by DTI and volumetric analyses.
- Authors
Gunbey, Hediye; Bilgici, Meltem; Aslan, Kerim; Has, Arzu; Ogur, Methiye; Alhan, Aslıhan; Incesu, Lutfi; Gunbey, Hediye Pınar; Bilgici, Meltem Ceyhan; Has, Arzu Ceylan; Ogur, Methiye Gonul; Alhan, Aslıhan
- Abstract
<bold>Objectives: </bold>To provide an initial assessment of white matter (WM) integrity with diffusion tensor imaging (DTI) and the accompanying volumetric changes in WM and grey matter (GM) through volumetric analyses of young children with Down's syndrome (DS).<bold>Methods: </bold>Ten children with DS and eight healthy control subjects were included in the study. Tract-based spatial statistics (TBSS) were used in the DTI study for whole-brain voxelwise analysis of fractional anisotropy (FA) and mean diffusivity (MD) of WM. Volumetric analyses were performed with an automated segmentation method to obtain regional measurements of cortical volumes.<bold>Results: </bold>Children with DS showed significantly reduced FA in association tracts of the fronto-temporo-occipital regions as well as the corpus callosum (CC) and anterior limb of the internal capsule (p < 0.05). Volumetric reductions included total cortical GM, cerebellar GM and WM volume, basal ganglia, thalamus, brainstem and CC in DS compared with controls (p < 0.05).<bold>Conclusion: </bold>These preliminary results suggest that DTI and volumetric analyses may reflect the earliest complementary changes of the neurodevelopmental delay in children with DS and can serve as surrogate biomarkers of the specific elements of WM and GM integrity for cognitive development.<bold>Key Points: </bold>• DS is the most common genetic cause of intellectual disability. • WM and GM structural alterations represent the neurological features of DS. • DTI may identify the earliest aging process changes. • DTI-volumetric analyses can serve as surrogate biomarkers of neurodevelopment in DS.
- Subjects
DIAGNOSIS of Down syndrome; MAGNETIC resonance imaging of the brain; CHILDREN with intellectual disabilities; COGNITIVE development; CORPUS callosum; DIFFUSION tensor imaging; VOLUMETRIC analysis; ANTHROPOMETRY; BRAIN; COGNITION; MAGNETIC resonance imaging; DOWN syndrome
- Publication
European Radiology, 2017, Vol 27, Issue 7, p3013
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4626-6