We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Dual-Phase Dual-Energy CT in Patients Treated with Erlotinib for Advanced Non-Small Cell Lung Cancer: Possible Benefits of Iodine Quantification in Response Assessment.
- Authors
Baxa, Jan; Matouskova, Tana; Krakorova, Gabriela; Schmidt, Bernhard; Flohr, Thomas; Sedlmair, Martin; Bejcek, Jiri; Ferda, Jiri
- Abstract
<bold>Objectives: </bold>To investigate the relationship of dual-phase dual-energy CT (DE-CT) and tumour size in the evaluation of the response to anti-EGFR therapy in patients with advanced non-small cell lung cancer (NSCLC).<bold>Methods: </bold>Dual-phase DE-CT was performed in 31 patients with NSCLC before the onset of anti-EGFR (erlotinib) therapy and as follow-up (mean 8 weeks). Iodine uptake (IU; mg/mL) was quantified using prototype software in arterial and venous phases; arterial enhancement fraction (AEF) was calculated. The change of IU before and after therapy onset was compared with anatomical evaluation in maximal transverse diameter and volume (responders vs. non-responders).<bold>Results: </bold>A significant decrease of IU in venous phase was proved in responders according to all anatomical parameters (p=0.002-0.016). In groups of non-responders, a significant change of IU was not proved with variable trends of development. The most significant change was observed using the anatomical parameter of volume (cut-off 73 %). A significant difference of percentage change in AEF was proved between responding and non-responders (p=0.019-0.043).<bold>Conclusion: </bold>Dual-phase DE-CT with iodine uptake quantification is a feasible method with potential benefit in advanced assessment of anti-EGFR therapy response. We demonstrated a decrease in vascularization in the responding primary tumours and non-significant variable development of vascularization in non-responding tumours.<bold>Key Points: </bold>• Dual-phase DE-CT is feasible for vascularization assessment of NSCLC with anti-EGFR therapy. • There was a significant decrease of iodine uptake in responding tumours. • There was a non-significant and variable development in non-responding tumours. • There was significant difference of AEF percentage change between responders and non-responders.
- Subjects
NON-small-cell lung carcinoma; DUAL energy CT (Tomography); ERLOTINIB; CONTRAST media; EPIDERMAL growth factor receptors; IODINE isotopes; DIAGNOSIS; THERAPEUTICS
- Publication
European Radiology, 2016, Vol 26, Issue 8, p2828
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-015-4092-6