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- Title
Usefulness of T1 mapping on Gd-EOB-DTPA-enhanced MR imaging in assessment of non-alcoholic fatty liver disease.
- Authors
Ding, Ying; Rao, Sheng-Xiang; Meng, Tao; Chen, Caizhong; Li, Renchen; Zeng, Meng-Su
- Abstract
Objectives: This study evaluates the value of Gd-EOB-DTPA-enhanced MRI for diagnosis and staging of non-alcoholic fatty liver disease (NAFLD) in an animal model by T relaxation time measurement. Methods: Thirty-four rabbits were divided into the control group ( n = 10) and NAFLD group, which was split into four groups ( n = 6) with a high-fat diet for an interval of 3 weeks. A dual flip angle was performed before and at the hepatobiliary phase (HBP). T relaxation times of the liver parenchyma and the decrease rate (∆%) were calculated. Histological findings according to semi-quantitative scoring of steatosis, activity and fibrosis were the standard of reference. Results: HBP and ∆% T relaxation time measurement showed significant differences between normal and NAFLD groups, between non-alcoholic steatohepatitis (NASH) and NAFLD without NASH ( p = 0.000-0.049), between fibrosis groups ( p = 0.000-0.019), but no difference between F1 and F2 ( p = 0.834). The areas under the receiver operating characteristic curves (AUCs) of T relaxation time for HBP and ∆% were 0.86-0.93 for the selection of NASH and activity score ≥2, and 0.86-0.95 for the selection of F ≥ 1, 2, 3. No significant difference was found for diagnostic performance between HBP and ∆% T relaxation time. Conclusions: HBP T relaxation time measurement of Gd-EOB-DTPA-enhanced MRI was useful to evaluate NAFLD according to the SAF score. HBP T relaxation time measurement was as accurate as ∆% T relaxation time. Key Points: • Gd-EOB-DTPA-enhanced MRI could give useful information on NAFLD. • HBP T relaxation time measurement was useful for the evaluation of NAFLD. • HBP T relaxation time measurement was as accurate as ∆%.
- Subjects
FATTY liver; LIVER disease diagnosis; ANIMAL models in research; MEDICAL imaging systems; CONTROL groups; MAGNETIC resonance imaging
- Publication
European Radiology, 2014, Vol 24, Issue 4, p959
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-014-3096-y