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- Title
Transarterial chemoembolisation: effect of selectivity on tolerance, tumour response and survival.
- Authors
Bouvier A; Ozenne V; Aubé C; Boursier J; Vullierme MP; Thouveny F; Farges O; Vilgrain V; Bouvier, Antoine; Ozenne, Violaine; Aubé, Christophe; Boursier, Jérôme; Vullierme, Marie Pierre; Thouveny, Francine; Farges, Olivier; Vilgrain, Valérie
- Abstract
<bold>Aims: </bold>To compare selective and non-selective TACE techniques in the treatment of HCC with a special emphasis on clinical and liver tolerance, tumour response and survival.<bold>Methods: </bold>184 patients with advanced HCC were retrospectively included. Three different TACE techniques were compared: non selective lipiodol-chemotherapy + non selective embolisation (TACE-technique group 1), non selective lipiodol-chemotherapy + selective embolisation (group 2), and selective lipiodol-chemotherapy + selective embolisation (group 3).<bold>Results: </bold>In multivariate analysis TACE-technique group is an independently significant prognostic factor for poor clinical tolerance, poor liver tolerance and tumour response. The rate of patients with poor clinical tolerance was lower in group 3 (27.0%) than in groups 1 (64.1%, p < 10(-3)) or 2 (66.7%, p < 10(-3)). The rate of patients with poor liver tolerance was higher in group 2 (34.0%) than in groups 1 (17.6%, p = 0.050) or 3 (6.9%, p = 0.011). The rate of patients with tumour response was higher when embolisation was selective versus non-selective, i.e., group 2 + 3 (78.7%) versus group 1 (62.5%, p = 0.054). Overall survival was not significantly different between the three groups (p = 0.383).<bold>Conclusion: </bold>Both selective techniques resulted in better tumour response. As for improving tolerance, our study suggests that the main technical factor is the use of selective lipiodol-chemotherapy injection.
- Publication
European Radiology, 2011, Vol 21, Issue 8, p1719
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-011-2118-2