We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Fluorescein-guided resection for pediatric low-grade gliomas: institutional experience on two cases and a narrative literature review.
- Authors
da Costa, Marcos Devanir Silva; Vaz, Herison Harrider Silva; Silva, Nicole A.; Dastoli, Patricia Alessandra; Nicácio, Jardel Mendonça; Malveira, Adib Saraty; Flores, Esdras Ismael Borrayo; Cavalheiro, Sergio
- Abstract
Purpose: Low-grade gliomas compose 30% of pediatric central nervous system tumors and outcomes of disease-free progression, and survival is directly correlated to the extent of resection. The use of sodium fluorescein (Na-Fl) is an intraoperative method in the localization of tumor cells in adult patients to optimize resection. Our purpose is to describe the use of Na-Fl in pediatric low-grade gliomas and its outcomes. Methods: Patients under 18 years of age with low-grade gliomas at the author's institution underwent resection with the use of Na-Fl, with review of preoperative imaging findings, intraoperative results, and follow-up. Then, a comprehensive, narrative literature review of the use of Na-Fl in pediatric low-grade glioma was performed. Results: Our single-institution use of Na-Fl in pediatric patients with suspected low-grade glioma demonstrated excellent results of intraoperative enhancement of tumor cells as well as gross total resection. The literature demonstrated 84% Na-Fl staining and 59.2% of gross total resection in pediatric low-grade gliomas with few small case studies, a range of reported findings, and few side effects. Conclusion: Na-Fl has a promising use in low-grade glioma resection in the pediatric patient population. Further research is warranted, such as randomized controlled studies, to assess Na-Fl as a potential tool in improving resection and long-term favorable outcomes.
- Subjects
LITERATURE reviews; GLIOMAS; CENTRAL nervous system tumors; CHILD patients; BRAIN tumors
- Publication
Child's Nervous System, 2023, Vol 39, Issue 6, p1485
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-022-05773-4