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- Title
CKD stage-to-stage progression in native and transplant kidney disease.
- Authors
Aleksandra Kukla; Madhurima Adulla; Julio Pascual; Millie Samaniego; Lisa Nanovic; Bryan N. Becker; Arjang Djamali
- Abstract
Background. Kidney half-life and inter-stage progression rates in native chronic kidney disease (CKD) and CKD-transplant (CKD-T) remain unknown. Methods. We examined stage-to-stage progression/regression rates in patients with CKD (n = 601) and CKD-T (n = 431) between 1991 and 2001. Kidney function was estimated by Cockcroft–Gault and MDRD eGFR formulae. Kaplan–Meier analyses determined progression and regression half-lives, defined as the time required for 50% of kidneys to advance towards a higher or lower stage of CKD, respectively. Results. Most (67%) of the patients were in stage 3. Patients with native CKD were more likely to progress compared to CKD-T (inter-stage progression rates 12 vs 4 cases per 100 patient-years, P vs 9.6 years, P Conclusion. Kidney half-lives per stage of CKD may be a novel tool to examine disease progression.
- Subjects
KIDNEY diseases; TRANSPLANTATION of organs, tissues, etc.; URINARY organ diseases; DIAGNOSIS
- Publication
Nephrology Dialysis Transplantation, 2008, Vol 23, Issue 2, p693
- ISSN
0931-0509
- Publication type
Article