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- Title
In vitro activity and serum protein-binding of cefaclor.
- Authors
Tally, Francis P.; Jacobus, Nilda V.; Barza, Michael; Tally, F P; Jacobus, N V; Barza, M
- Abstract
The susceptibility of anaerobic and aerobic bacteria to cefaclor, cephalexin, and penicillin G were compared. Cefaclor was two- to fourfold more inhibitory than cephalexin against susceptible Gram-negative bacilli and . Both drugs were active against streptococci and anaerobes other than but were distinctly less potent than penicillin G. Ultrafiltration serum protein-binding studies revealed that cefaclor was approximately 50% bound while the corresponding value for cephalexin was only 17 to 20%. The results indicate that cefaclor is moderately more active than cephalexin against and susceptible Gram-negative bacilli, but suggest that oral cephalosporins should be used with caution in anaerobic infections.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1979, Vol 5, Issue 2, p159
- ISSN
0305-7453
- Publication type
journal article