We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Age-Related Differences in Neutralizing Antibody Responses against SARS-CoV-2 Delta and Omicron Variants in 151 SARS-CoV-2-Naïve Metropolitan Residents Boosted with BNT162b2.
- Authors
Beomki Lee; Go Eun Bae; In Hwa Jeong; Jong-Hun Kim; Min-Jung Kwon; Jayoung Kim; Byoungguk Kim; June-Woo Lee; Jeong-Hyun Nam; Hee Jin Huh; Eun-Suk Kang
- Abstract
Background: Although age negatively correlates with vaccine-induced immune responses, whether the vaccineinduced neutralizing effect against variants of concern (VOCs) substantially differs across age remains relatively poorly explored. In addition, the utility of commercial binding assays developed with the wild-type SARS-CoV-2 for predicting the neutralizing effect against VOCs should be revalidated. Methods: We analyzed 151 triple-vaccinated SARS-CoV-2-naïve individuals boosted with BNT162b2 (Pfizer-BioNTech). The study population was divided into young adults (age < 30), middle-aged adults (30 ≤ age < 60), and older adults (age ≤ 60). The plaque reduction neutralization test (PRNT) titers against Delta (B.1.617.2) and Omicron (B.1.1.529) variants were compared across age. Antibody titers measured with commercial binding assays were compared with PRNT titers. Results: Age-related decline in neutralizing titers was observed for both Delta and Omicron variants. Neutralizing titers for Omicron were lower than those against Delta in all ages. The multiple linear regression model demonstrated that duration from third dose to sample collection and vaccine types were also significant factors affecting vaccine-induced immunity along with age. The correlation between commercial binding assays and PRNT was acceptable for all age groups with the Delta variant, but relatively poor for middle-aged and older adults with the Omicron variant due to low titers.
- Subjects
SARS-CoV-2 Omicron variant; SARS-CoV-2 Delta variant; OLDER people; BINDING site assay; ANTIBODY titer; YOUNG adults; MIDDLE-aged persons
- Publication
Journal of Applied Laboratory Medicine, 2024, Vol 9, Issue 4, p741
- ISSN
2475-7241
- Publication type
Article
- DOI
10.1093/jalm/jfae014