We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper.
- Authors
Palmer, Ed; Naeher, Dieter
- Abstract
The affinity of the T-cell receptor (TCR) for self antigen is the basis for the selection of a useful (MHC-restricted) and safe (self-tolerant) T-cell repertoire. However, it has been difficult to understand how thymocytes measure ligand affinity and translate this signal into a cellular response. In this Opinion article, we propose a new model that describes how the TCR discriminates between low- and high-affinity ligands, which is based on the duration of TCR-ligand interactions and a 'zipper' mechanism that mediates the interaction of the TCR and co-receptor molecules to initiate negative-selection signalling.
- Subjects
T cell receptors; MAJOR histocompatibility complex; LIGANDS (Biochemistry); CELL membranes; CELL communication; ANTIGENS; CELL receptors; GENES; HEMATOPOIESIS; IMMUNITY; MICE; T cells; THYMUS
- Publication
Nature Reviews Immunology, 2009, Vol 9, Issue 3, p207
- ISSN
1474-1733
- Publication type
research
- DOI
10.1038/nri2469