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- Title
What does the future hold for cell-based tolerogenic therapy?
- Authors
Bluestone, Jeffrey A.; Thomson, Angus W.; Shevach, Ethan M.; Weiner, Howard L.
- Abstract
Evidence from animal models has shown that the transfer of regulatory T cells or tolerogenic dendritic cells can prevent or cure transplant rejection or re-establish self-tolerance in autoimmune disease. The potential of these tolerogenic cells for the treatment of T-cell-mediated diseases in humans has gained momentum in recent years. Here, Nature Reviews Immunology asks four leading researchers to provide their view on the future of cell-based tolerogenic therapy and to highlight some important issues that must be considered before this form of immunotherapy can become a reality.
- Subjects
T cells; DENDRITIC cells; AUTOIMMUNE diseases; IMMUNOTHERAPY; CELLULAR therapy; ANIMAL models in research; AUTOIMMUNE disease treatment; ANIMALS; FORECASTING; IMMUNIZATION; IMMUNOLOGICAL tolerance
- Publication
Nature Reviews Immunology, 2007, Vol 7, Issue 8, p650
- ISSN
1474-1733
- Publication type
review
- DOI
10.1038/nri2137