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- Title
Fluoxetine Promotes Longevity via Reactive Oxygen Species in Caenorhabditis elegans.
- Authors
Zhou, Can; Zhou, Yiming; Liang, Yu; Chen, Lijuan; Liu, Li; Wei, Fang; Li, Guolin
- Abstract
Although several antidepressants have been identified as potential geroprotectors, the effect and mechanism of fluoxetine, a representative selective serotonin reuptake inhibitor, on longevity have not been fully elucidated. Here, we found that fluoxetine promoted longevity in Caenorhabditis elegans with a concomitant extension of a healthy life span as indicated by increasing mobility, reducing fertility and lipofuscin accumulation, and enhanced resistance to different abiotic stresses. Fluoxetine increased the level of reactive oxygen species (ROS), and antioxidant N-acetylcysteine abolished ROS elevation and the pro-longevity effect of fluoxetine. Additionally, fluoxetine extended life span through the daf-2 - sod-3 pathway in daf-16 -dependent and -independent manners, and fluoxetine-induced life-span extension was abolished in C. elegans sod-3 , daf-2 , and daf-16 mutants. In conclusion, these findings suggest that fluoxetine can promote health and longevity in C. elegans via the interaction of ROS and insulin signaling.
- Subjects
LIFE spans; REACTIVE oxygen species; CAENORHABDITIS elegans; FLUOXETINE; SEROTONIN uptake inhibitors; LONGEVITY
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2024, Vol 79, Issue 1, p1
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/glad220