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- Title
宫腔镜电切术联合左炔孕酮宫内节育系统对子宫内膜息肉患者性激素、 炎症因子及复发的影响.
- Authors
陈红霞; 方春丽; 王 辉; 胡菲菲; 应小燕
- Abstract
Objective: To investigate the effect of hysteroscopic resection combined with levonorgestrel intrauterine contraceptive system (LNG-IUS) on sex hormones, inflammatory factors and recurrence in patients with endometrial polyps. Methods: 98 patients with endometrial polyps in our hospital from April 2016 to April 2018 were selected, and randomly divided into control group and combined group, 49 cases in each group. The control group was treated with hysteroscopic resection, and the combined group was treated with hysteroscopic resection combined with LNG-IUS. The sex hormones, inflammatory factors and recurrence of the two groups were compared, and the incidence of adverse reactions in the two groups was recorded. The menstrual cycle, menstrual volume and endometrial thickness of the two groups were observed. Results: 6 months after operation, the menstrual period, menstrual volume and endometrial thickness of the two groups were lower than those before operation, and those of the combined group were lower than those of the control group (P<0.05). There were no significant differences in follicle-generating hormone (FSH), luteinizing hormone (LH), estradiol (E2) between the two groups before and 6 months after operation(P>0.05). 6 months after operation, the interleukin-6(IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) in the two groups were lower than those before operation, and those of the combined group were lower than those of the control group(P<0.05), and the interleukin-4 (IL-4) increased, and that of the combined group was higher than that ofthe control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The recurrence rate of the combined group was lower than that of the control group (P<0.05). Conclusion: Hysteroscopic resection combined with LNG-IUS in the treatment of endometrial polyps can effectively prevent the growth of endometrial polyps, reduce the recurrence rate, and have little effect on the levels of sex hormones. The mechanism may be related to the inhibition of inflammatory reaction.
- Subjects
LEVONORGESTREL intrauterine contraceptives; ENDOMETRIAL hyperplasia; DISEASE relapse; MENSTRUAL cycle; INTERLEUKIN-6; C-reactive protein; HYSTEROSCOPY; POLYPECTOMY
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 20, p3691
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.19.018