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- Title
急性心力衰竭患者血清Adropin、sST2、Gal-3 水平与预后的关系分析.
- Authors
赵颖超; 额尔敦其木格; 戴军有; 郭欣君; 格日勒
- Abstract
Objective: To investigate the relationship between serum Adropin, soluble ST2 receptor (sST2) and galactose lectin-3 (Gal-3) levels and prognosis in patients with acute heart failure. Methods: 154 patients with acute heart failure who were admitted to People's Hospital of Inner Mongolia Autonomous Region from June 2015 to June 2019 were enrolled in the heart failure group, another 100 volunteers who underwent health examination in the same period were selected as the control group. The Adropin, sST2 and Gal-3 levels in heart failure group and control group were compared. The heart failure group were divided into three groups according to American New York Heart Association (NYHA) classification: class II group (n=38), class III group (n=64) and class IV group (n=52). The Adropin, sST2 and Gal-3 levels among the three groups were compared. The patients in heart failure were divided into good prognosis group (n=95) and poor prognosis group (n=59) according to the prognosis of patients after discharge. Univariate and Logistic multiple regression were used to analyze the influencing factors of poor prognosis in patients with acute heart failure. Results: Adropin, sST2 and Gal-3 levels in heart failure group were higher than those in control group (P<0.05). The Adropin, sST2 and Gal-3 levels in patients with heart failure group increased significantly with the increase of heart function classification (P<0.05). 59 patients had poor prognosis, the incidence was 38.31%. Univariate analysis showed that there were no significant differences in age, gender, body mass index (BMI), smoking history, drinking history, basic diseases and Blood Routine Indexes between the poor prognosis group and the good prognosis group (P>0.05). Cardiac function classification, serum Adropin, sST2 and Gal-3 levels in patients with poor prognosis group were higher than those in patients with good prognosis group (P<0.05). Logistic multivariate regression analysis showed that class IV, Adropin≥ 10 ng/mL, sST2≥ 150 µg/mL and Gal-3≥ 5 µ g/L were risk factors for poor prognosis in patients with acute heart failure (P<0.05). Conclusion: The serum Adropin, sST2 and Gal-3 levels in patients with acute heart failure are increased significantly, and they are increased with the aggravation of the disease. The changes of serum Adropin, sST2 and Gal-3 levels would affect the prognosis of patients.
- Subjects
INNER Mongolia (China); HEART failure patients; BODY mass index; LOGISTIC regression analysis; PERIODIC health examinations; AGE differences
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 7, p1326
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.07.027