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- Title
帕瑞昔布联合股神经阻滞用于膝关节置换术后镇痛的效果评价 及其对患者免疫功能的影响
- Authors
何家璇; 孟丽华; 袁浩峥; 张勇; 吴刚
- Abstract
Objective: To explore the analgesia effect of parecoxib combined with femoral nerve block after the knee replacement operation and its effect on the immune function. Methods: 108 cases of patients who underwent unilateral knee replacement in our hospital from October 2016 to October 2017 were selected and divided into the control group and the observation group by analgesic method, with 54 cases in each group. Patients in the control group were treated with femoral nerve block, while patients in the observation group were treated with femoral nerve block combined with parecoxib. The VAS score, HSS score, the occurrence of adverse reactions and the changes of immune indexes were compared between the two groups. Results: The VAS score of resting and activity of observation group were lower than those of the control group(P<0.05). The HSS score of observation group was significantly higher than that of the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). At the end of the operation, the CD4+ of both groups were significantly lower than those before anesthesia(P<0.05). There was no significant difference in the CD4+, CD8+ and CD4+/CD8+ between the two groups(P>0.05). CD4+/CD8+ was significantly lower in the observation group than that in the control group(P<0.05). Conclusions: Parecoxib combined with femoral nerve block for postoperative analgesia after knee replacement is good, it can improve the immune function of patients and promote the rehabilitation of knee function.
- Subjects
FEMORAL nerve; NERVE block; CONTROL groups; ANALGESIA; KNEE; ANESTHESIA
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 19, p3673
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.19.016